Brigatinib is indicated for anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients who have progressed on or are intolerant to crizotinib
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Non-small cell lung cancer (NSCLC) is a type of lung cancer in which malignant cells form in the tissues of the lung. It is one of the two main types of lung cancer, the other being small-cell lung cancer. NSCLC accounts for approximately 85% of all lung cancer cases.
Types of Non-Small Cell Lung Cancer: There are several subtypes of NSCLC, each characterized by the type of cells involved. The main types include:
Other Less Common Types are adenosquamous carcinoma, sarcomatoid carcinoma, salivary gland carcinoma, carcinoid tumor, and unclassified carcinoma.
Risk Factors: The major risk factor for NSCLC is smoking, whether it be cigarettes, pipes, or cigars. Other risk factors include exposure to secondhand smoke, occupational exposure to certain substances like asbestos and arsenic, radiation exposure, living in areas with air pollution, and having a family history of lung cancer. Older age is also a significant risk factor, and when combined with smoking, the risk increases.
Signs and Symptoms: Signs and symptoms of NSCLC may include persistent cough, shortness of breath, chest pain, wheezing, blood in sputum, hoarseness, loss of appetite, unexplained weight loss, fatigue, trouble swallowing, and swelling in the face or neck veins.
Diagnosis and Staging: Diagnosing NSCLC involves various tests and procedures, including laboratory tests, chest x-rays, CT scans, sputum cytology (examining coughed-up mucus for cancer cells), and thoracentesis (removal of fluid for examination). If lung cancer is suspected, a biopsy is performed to confirm the diagnosis.
Treatment and Prognosis: Treatment options for NSCLC may include surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy, or a combination of these. Prognosis and treatment depend on the stage of cancer, overall health, and other factors. For most patients, current treatments may not cure the cancer, but they can help manage and control the disease.
Non-Small Cell Lung Cancer
Brigacent 180 Tablet is indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic Non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to Crizotinib.
Brigatinib is a tyrosine kinase inhibitor with in vitro activity against multiple kinases, including ALK, ROS1, IGF-1R, FLT-3, and EGFR deletion/point mutations. It inhibits the autophosphorylation of ALK and downstream signaling proteins. Brigatinib has shown antitumor activity in various assays and animal models.
Brigacent 180 Tablet is contraindicated in patients with known hypersensitivity to Brigatinib or any other components of this product.
Brigatinib, like any medication, may cause both common and serious side effects. It's important to communicate with your doctor about any symptoms you experience. Here are the potential side effects of brigatinib:
If you experience any of the following symptoms, contact your doctor immediately or seek emergency medical attention:
It's essential to inform your doctor about any unusual problems or symptoms you may experience while taking brigatinib.
The use of contraception is emphasized during brigatinib treatment due to potential risks. Here are the recommendations:
For Females:
For Males:
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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